Oscar Isaac's Spider-Man 2099 will be an antagonist to Shameik Moore’s Miles Morales in Across the Spider-Verse.
In the latest trailer for Spider-Man: Across the Spider-Verse, Oscar Isaac appears to be taking the villainous role against Shameik Moore’s Miles Morales, leading the assembled Spider-Society against the youthful hero. In fairness, it seems that Oscar Isaac’s Miguel O’Hara (aka Spider-Man 2099) is more of an antagonist than a complete bad guy; the latter role is filled by the Spot (Jason Schwartzman), who also makes an appearance in the trailer. On the other hand, it does not seem like Miguel O’Hara is really maintaining his chill and is actually kind of scary.
The much-anticipated sequel to Spider-Man: Into the Spider-Verse brings Miles Morales back for another Multiversal adventure, this time seemingly in pursuit of the Spot. It seems the monochromatic villain (whose black-and-white spots do indeed make him look a bit like a cow, as Miles quips) has the ability to travel through the Multiverse at will, which presumably leads to our hero finding himself back to encountering different variants of himself. However, it seems that Oscar Isaac has a real beef with Miles, leading to one Spider-Man facing off against many, many Spider-People.
It is not exactly clear why Spider-Man 2099 has such animosity toward Miles Morales, to the point of telling the young superhero that he will never be a part of the assembled Spider-Society, which is one of many factions helping to keep the Multiverse together, including the Time Variance Authority seen in the Disney+ series Loki and Doctor Strange’s whole deal. Interestingly, Doctor Strange gets a shout-out from Oscar Isaac, even though Benedict Cumberbatch’s character is part of the MCU and Spider-Man 2099 is part of Sony Pictures.
Specifically, Oscar Isaac refers to some irritation caused by Doctor Strange and “the little nerd back on Earth-199999,” which seems to be an allusion to Spider-Man: No Way Home, in which the duo of Benedict Cumberbatch and Tom Holland really messed up things in pursuit of college acceptance letters and brought a bunch of whole bunch of extradimensional visitors to the MCU. Oddly, it was previously asserted in Doctor Strange in the Multiverse of Madness that the MCU was Earth-616 (the standard assigned number for mainstream Marvel Comics), so it is unclear exactly what Isaac meant by Earth-199999.
That might just be a throwaway reference in Across the Spider-Verse, though it has been rumored that Miles Morales will enter the MCU and encounter live-action Tom Holland. We also know that we’ll be seeing Spider-Punk (Daniel Kaluuya), Spider-Woman (Issa Rae), and Spider-Man India (Karan Soni) in their native dimensions. We’ll also get returning Spider-People Gwen Stacy (Hailee Steinfeld) and Peter B. Parker (Jake Johnson), so at least there will be a few people on Miles Morales’ side against Oscar Isaac.