Hey, Big Government and Big Pharma, science is catching up. No, I’m not actually that kind of conspiracy theorist, but like many other people, I’ve naively wondered why cancer treatments seemed to be stuck in stasis. I know it’s worlds more complicated than “Chemo and radiation might help,” but that is what it boils down to.
The journal Nature Biotechnology reports that Australian researchers, including molecular biologist Dr. Himanshu Brahmbhatt, have treated tumor cells of mice using minicells, made from bacteria and short interference RNA (siRNA), which counteract the cancer cells’ genes responsible for resisting drug treatments. Once those cells are weakened, they become sensitive to chemotherapy treatments again. Seems obvious, doesn’t it?
Well, it was previously thought that siRNA couldn’t pass through cell membranes due to their size, but bacterial membranes contain protein channels that siRNA can enter. The outsides of the minicells are coated with antibodies, which lock onto receptors in tumor cells. The minicells then enter the cancer cells and break down to where the siRNA is dispersed throughout the cell. Because this particular effect happens intra-cellularly, no toxic effects have been found.